The reigning NFC Champion San Francisco 49ers are, once again, expected to rule the NFC West, coming in at -125 moneyline odds to win their third consecutive division title. Most odds makers anticipate another NFC Championship appearance from the Niners as well with San Francisco the current Super Bowl Odds favorite from the NFC at +650 odds ($100 wins $650).

 

The latest NFL game lines from Vegas based Cantor Gaming have the 49ers favored in all but two of their first 16 games (Week 17 lines not available). San Francisco is listed as a +2.5 against the spread road dog in its Week 2 clash with the Seahawks in Seattle and its Week 11 meeting with the Saints in New Orleans is presently lined as a pick’em.

 

San Francisco is listed as -7 or more against the spread favorite in no fewer than five games (Indianapolis, Arizona, at Tennessee, at Jacksonville, St. Louis).

 

 

San Francisco 49ers Odds to Win the NFC West -125 (one of four)

San Francisco 49ers Odds to Win Super Bowl XLVIII +650 (three of 32)

 

Week 1: San Francisco (-4) vs Green Bay 4:25pm ET FOX

Week 2: San Francisco (+2.5) @ Seattle 8:30pm ET NBC

Week 3: San Francisco (-7.5) vs Indianapolis 4:25pm ET CBS

Week 4: San Francisco (-4) @ St. Louis 8:25pm ET NFL Network

Week 5: San Francisco (-5.5) vs Houston 8:30pm ET NBC

Week 6: San Francisco (-10) vs Arizona 4:25pm ET FOX

Week 7: San Francisco (-7) @ Tennessee 4:05pm ET FOX

Week 8: San Francisco (-10.5) @ Jacksonville (London) 1:00pm ET FOX

Week 9: BYE

Week 10: San Francisco (-6) vs Carolina 4:05pm ET FOX

Week 11: San Francisco (PK) @ New Orleans 4:25pm ET FOX

Week 12: San Francisco (-1.5) @ Washington 8:30pm ET ESPN

Week 13: San Francisco (-7.5) vs St. Louis 4:05pm ET FOX

Week 14: San Francisco (-2.5) vs Seattle 4:25pm ET FOX

Week 15: San Francisco (-3) @ Tampa Bay 1:00pm ET FOX

Week 16: San Francisco (-3.5) vs Atlanta 8:30pm ET ESPN

Week 17: San Francisco (NA) @ Arizona 4:25pm ET FOX