The Bills will attempt to bounce back from last week’s shellacking when they tangle with, perhaps, the NFC’s best team, the San Francisco 49ers (4:25pm ET start time, CBS). NFL Sunday Buffalo Bills vs San Francisco 49ers odds have Jim Harbaugh’s troops laying 10 points in this inter-conference skirmish while the game total is set at 45 points. Buffalo is presently listed as a -360 moneyline play to hand the Niners their second loss of the season.

San Francisco wasted little time recovering from its shocking upset at Minnesota as it took to the road last week and pounded the Jets 34-0. The Niners offense had an impressive afternoon, piling up 26 first downs and 379 total yards, but its defense stole the show. New York managed all of nine first downs and 145 total yards for the game and it had four turnovers in the lopsided contest.

San Francisco returns home this today for just the second time this season and it will face a Bills squad still punch drunk from the 52-28 trouncing it absorbed from New England last Sunday.

Things started well enough for 2-2 Buffalo against the Patriots as it jumped out to a 21-7 lead, but the second half saw the team surrender six touchdowns to Tom Brady and company.

The Bills will not have to worry about the same type of offensive assault from San Francisco this afternoon, but they can also rest assured their will be no 21-7 first half lead.

Not a good spot for the Bills here as the Niners are against the spread gold at home under Jim Harbaugh. San Francisco is 10- straight up and 7-3 against the spread in its last 10 games as a home favorite with a spread between 8 and 10.5 points and it is 9-1 both straight up and against the spread in its last 10 games as a home favorite.

Free Pick: Take San Francisco -10.

Buffalo Bills vs San Francisco 49ers NFL Sunday Odds:

Buffalo Bills +10 (-110), Over 45 (-110), +360 (Moneyline)

San Francisco 49ers -10 (-110), Under 45 (-110), -460 (Moneyline)

NFL Free Picks: San Diego Chargers at New Orleans Saints Betting
What pro football bettors need to know about San Diego Chargers at New Orleans Saints on Sunday (10/07/12) - a free pick from Pregame.com's Marco D'Angelo, with Bryan Leonard and host Scott Spreitzer.

-25 of picks FREE! No Obligation - No Credit Card Required - Becoming a member is Fast and Free!

Want to find great NFL information and college football information? Then hit the Pregame Forum now, just click here!

Get great insight and NFL secrets from RJ Bell, click here now!