Given their injuries, the Red Sox have done well to open the season 10-9. Boston has received outstanding starting pitching and power from Tyler O'Neil, who is second in the majors in homers with seven.

But the Red Sox are in trouble in this game. O'Neil is likely to miss his third straight game because of a concussion. Boston's bullpen is below average and this is going to be a bullpen game for them. 

Reliever Brennan Bernardino is slated to start for the Red Sox. He's only expected to pitch one or two innings followed by Cooper Criswell. The Red Sox have a 4.11 bullpen ERA.

By contrast, the Guardians rank No. 2 in the majors in bullpen ERA at 2.15. This is a huge plus for Cleveland's aged starter Carlos Carrasco, who has allowed two earned runs during his past 7 2/3 innings and has a respectable 3.55 ERA. 

Given these circumstances, I'll go with the Guardians especially in an underdog role.