Both team's offenses are heating up. 

After five games, the 49ers are showing signs of picking up Kyle Shanahan's intrigue schemes and designs. Brian Hoyer is coming off his best game as a 49er throwing for two touchdown passes and 353 yards while compiling a 101.1 passer rating against the Colts on the road last week. The Redskins will be without their elite cornerback, injured Josh Norman.

Shanahan and Pierre Garcon, who is having a good year for the 49ers, know the Redskins well. Shanahan was Washington's offensive coordinator from 2010-2013 while Garcon played the previous five seasons for the Redskins. They will know the soft spots in the Redskins' coverage. 

Kirk Cousins is back on track for Washington. He's 39-for-54 for 585 yards with a five-to-zero touchdown-to-interception ratio in his last two games. The Redskins will be fresh having had their bye last week. The time off has allowed star tight end Jordan Reed to be healthy for the first time this season. 

The 49ers defense gives up the fifth-most yards per game and is second-to-last in opponent's third-down percentage. San Francisco's defense could get tired early, too. 

This marks San Francisco's third consecutive road game. It's an early start time, too, for the 49ers. The 49ers defense has had to endure overtime games the past two weeks. They've been on the field 37:17 and 36:15 during the past two games.