The Seahawks have dominated the 49ers at home winning the past six times. They've beaten San Francisco by 19 and 16 points, respectively, the past two years. 

Seattle has the top defense in the NFL. All of the Seahawks' defensive studs are back and run-stuffer Sheldon Richardson has been added. The 49ers' work-in-progress offense isn't ready for this caliber of defense, especially in the toughest outdoor road venue. San Francisco could only manage three points and 217 yards of offense at home against Carolina this past Sunday. 

Russell Wilson has the best set of receivers he's ever had. Wilson is primed for a huge year. The 49ers defense took a huge loss when promising rookie linebacker Reuben Foster suffered a high ankle sprain this past Sunday. 

The Seahawks are in a foul mood after losing to the Packers opening week. They'll take their frustrations out on the hapless 49ers here.