Jackpot, I think that would be a wise play. Florida is nearly a lock to cover and I would say a very probable bet to win outright.
The loss of Del Rio is a non factor. I think people are overvaluing his importance. Now Callaway on the other hand would hurt, but it looks as though he will play.
Florida's defense, especially in the secondary, is complete shutdown. The Vols will have to run to score, they'll get nothing in the passing game.
Florida has excellent special teams kickers. They will win field position.