Over 2.5 goals in the LC v. Chelsea match is worth a look. Managers tend to rotate their squads in EFL cup matches. My bet will depend on how Chelsea lines up. I don't expect to see Costa & Hazard in the starting XI but also expect to see a few inexperienced defenders be inserted for both teams. Chelsea's second selection attack force of Batschaya, Pedro & Loftus-Cheek will want to impress the new manager & will work hard to score goals. LC plays best when on the counter attack, hence why I see over 2.5 goals as the play.
I like Dortmund v. Wolfsburg to go under 3 goals. Wolfsburg has been solid in the back and Dortmund are coming off consecutive games over scoring 6 goals. They are great in attack but it is tough to continue to score at such a rate. Dortmund also play on Friday, so I doubt their best XI will be on the field.
Milan did win away at Sampdoria last Friday, but Sampdoria did have two goals incorrectly ruled out. Lazio are not a bad side & should score at least one goal. Would not be surprised to see a 1 -1 draw.
For all soccer bets, it's usually best to wait until the team sheets have been announced.
Just some thoughts & insight...by no means is this full proof.