Patrick Mahomes is 9-3-1 against the spread (ATS) on the road in his career, and the over is 10-3 in those games.
New Orleans has covered in six straight games, the longest active streak in the NFL. Meanwhile, Atlanta is 7-17 ATS over the past two seasons, the worst mark in the NFL (2-6 ATS this season, tied for worst in the NFL).
Detroit has failed to cover three straight games, and Chicago has failed to cover four straight. In the past 20 years, the team with the better season ATS record is 23-4 ATS in matchups in which both teams enter the game with at least three-game losing streaks ATS. So far this season, Detroit is 4-4 ATS and Chicago is 2-6.
Jameis Winston is 4-11 ATS and 7-8 straight up as a favorite in his career. And he is 1-7 ATS and 3-5 straight up as a favorite of at least three points.
Baltimore is 33-0 all time as a double-digit favorite, the only active franchise to never lose such a game. However, over the past 10 seasons, Baltimore is just 3-10 ATS in those games (0-2 this season).
Buffalo vs Cleveland This is the seventh time in the past 25 seasons that a team with a .250 or lower winning percentage is favored over a team with a .750 or better winning percentage in Week 6 or later. The favorite is 6-0 ATS in the previous six games. And it's just the third time in the Super Bowl era it's happened in Week 10 or later (2-0 ATS previously).
Giants vs Jets In the past five seasons, there have been 15 matchups in Week 6 or later between two teams with winning percentages of .250 or lower. In all 15 games, the underdog covered, going 14-1 straight up.
Miami has covered four consecutive games after starting the season 0-4 ATS. It's the second-longest active cover streak in the NFL behind only New Orleans (six straight).
Sean McVay is 10-0 straight up and 7-2-1 ATS against AFC teams in regular-season games.
Panthers quarterback Kyle Allen is 6-1 ATS and straight up as a starter (3-1 as an underdog). In the past 10 seasons, the only quarterbacks to start their careers 7-1 or better ATS are Patrick Mahomes, Dak Prescott, Brian Hoyer and Andy Dalton.
Minnesota is 0-7-1 both ATS and straight up in Cousins' starts on the road against teams that entered with winning records.
Wilson is 12-3 ATS and straight up in his career against San Francisco. However, San Francisco is 2-3 ATS in his past five games.