With 2:29 left in the extra period, James brought referee Rodney Mott over to the sideline and demonstratively pointed and gestured at two fans. An arena official approached, then another, and after a brief conversation with Mott, the officials escorted a man and a woman from their first-row seats on the floor.
As they left the court, the woman appeared to make a pouting face and crying motion in James' direction.
After the game, James did not elaborate on what the fans specifically said or did, only describing their actions as "outside the line with obscene gestures and words."
"When obscene gestures and language come into it, (it) can’t be tolerated," James said. "There's a difference from cheering for your team and not wanting the other team to win and things I would never say to a fan and they shouldn't say to me."
James scored 17 points in the fourth quarter and overtime Wednesday to help Los Angeles prevail without Anthony Davis, who sat out with an illness. James missed the Lakers' game Tuesday while serving a one-game suspension for striking the Detroit Pistons' Isaiah Stewart in the face earlier this week.
"I was excited about being in the lineup," James said. "I knew I could kind of give our guys a boost of energy with me not playing (Tuesday) night."