This has all the markings of a pick'em type game between two solid no-frill teams. 

Carson Wentz quietly is having a good season. He has just one interception, fewest of any starting quarterback, and has thrown multiple TD passes in each of his last three games. The Colts' stud offensive line is getting healthier. Jonathan Taylor gives Indy the best running back on the field by far. 

This is a huge game for Colts' star defensive lineman DeForest Buckner going against his former team. 

The 49ers have lost their last six home games. They are 0-8 ATS as home chalk. I find Kyle Shanahan to be perhaps the most overrated coach in the NFL. 

Jimmy Garoppolo is back at QB. Trey Lance isn't expected to play due to a knee injury. Garoppolo is much easier to game plan against. He wasn't mobile to begin with and now he's returning from a calf injury. The 49ers have yet to find their lead running back and star tight end George Kittle is on the injured list. 

The Colts are plus 7 in takeaways/giveaways. The 49ers, by contrast, have a minus-5 turnover ratio. The 49ers have multiple injuries in their secondary. 

There's a chance of rain and wind in the 10-15 mph range. This favors the better rushing team, which the Colts are because of Taylor.