Whether it's Jimmy Garoppolo or Trey Lance behind center, I want the 49ers going for me here. San Francisco is 10-4 ATS the past 14 times as an underdog and catch the Cardinals, the lone unbeaten team in the NFL, fat and happy after they ended an eight-game losing streak to the Rams with their impressive, 37-20, victory last Sunday.
San Francisco is 2-2, but aren't that far from being 4-0. They nearly pulled off a comeback against the Packers and they outgained the Seahawks by 223 yards in their one-score loss to Seattle last week. The 49ers have held their last three foes - Eagles, Packers and Seahawks - to an average of 305 yards.
Kyler Murray is the early frontrunner for MVP. The Cardinals have played three weak defenses, though, in the Titans, Vikings and Jaguars.
Kliff Kingsbury has been terrible in this role as the Cardinals are 1-8 ATS as a home favorite during the Kingsbury era.