From Sweet 16 to Final Four, favorites won only 4 of 12 games (underdogs winning 8 games straight-up)

With 12 games between the Sweet 16 and Final Four, there are 4,096 possible bracket outcomes – meaning a random guesser would have a 4,096 to 1 chance of picking all 12 winners. The odds against picking all 12 winners according to Vegas odds were actually 16,490 to 1 – over FOUR TIMES LESS LIKELY than random.

How improbable has the VCU run been?

VCU were underdogs in all 5 wins.
Their opponents were favored by a combined 34 points.
In those 5 wins, VCU covered the spread by a combined 94 points!

USC was favored by 4.5, and VCU had a 33% chance of winning.
Georgetown was favored by 5.5, and VCU had a 31% chance of winning.
Purdue was favored by 9.5, and VCU had an 18% chance of winning.
Florida State was favored by 4, and VCU had a 36% chance of winning.
Kansas was favored by 10.5, and VCU had an 11% chance of winning.

Win over Kansas was biggest upset of the Tournament. Win over Purdue was tied for second biggest upset of the Tournament.

The odds of VCU winning all 5 games: 1,371 to 1 against.
Meaning, If you started w/$10, and bet VCU (money line) and let your winnings ride on all 5 of their NCAA games, you'd have $13,714

Future Odds:

NONE of Top 10 pre-tournament favorites made Final Four. Kentucky #11 (25-1); U Conn #14 (32-1); Butler #33 (200-1); VCU #42 (350-1)