Listed below are a half-dozen of the top games on this weekend's College and NFL cards. With upsets galore happening on a weekly basis, let's see how many of the these matchups have upset potential.

Remember, Series History reflects results in head-to-head battles between the two teams.  All results are ATS (Against The Spread) unless noted otherwise.

COLLEGE FOOTBALL

Virginia Tech at Boston College

Series History: Hokies beat the Eagles, 30-16, in ACC title game last year.  Boston College is 6-1 in the last seven regular season meetings.

Virginia Tech Key Stat: Beamer is 19-8-2 as a conference dog of more than 1 point.

Boston College Key Stat: The Eagles are 6-1 ATS at home with rest.

You Need To Know: The combined win-loss record of BC's lined game opponents is 5-13 this season.  They are 0-1 in their only game against a winning opponent.

Missouri at Texas

Series History: Longhorns beat the Tigers, 50-21, in last meeting in 2005 in Columbia, the 3rd worst Big 12 Conference loss of Gary Pinkel's career.

Missouri Key Stat: Tigers are 17-3 SU in their their 20 games.

Texas Key Stat: Longhorns have scored on 32 of 33 possessions in the "red-zone" this season.

You Need To Know: Texas' leap from No. 5 to No.1 in the polls was the largest jump in the last 20 years.

LSU at South Carolina

Series History: LSU beat SC, 28-16, as 17.5-point home favorites last season. They are 6-1-1 SU and 4-4 ATS in the series against the Gamecocks since 1982.

LSU Key Stat: Bengals are 9-0 SU and 7-1-1 ATS in games off a loss the last six years.

South Carolina Key Stat:  Steve Spurrier is 1-7 SU and 2-6 ATS as a home dog of 4 or less points.

You Need To Know: Defending National Champions are 19-1 SU and 15-4 ATS in games off their 1st loss of the season the last 20 years.

NATIONAL FOOTBALL LEAGUE

San Diego at Buffalo

Series History: San Diego beat Buffalo, 24-21, here in 2006 as 6-point favorites.  The host is 5-2-1 the last 8 games in the series.

San Diego Key Stat: The Chargers allow 53 YPG more than they gain this season.

Buffalo College Key Stat: Dick Jauron is 15-2 off a loss versus a non-division opponent off a win.

You Need To Know: San Diego is 0-13 as a pick or favorite off a win versus AFC East opponents.

Minnesota at Chicago

Series History: Minnesota beat Chicago twice last season.  The Bears are 6-3 the last 9 games in the series.

Minnesota Key Stat:  Vikings are 2-14 as road dogs versus and opponent off a SU and ATS loss.

Chicago Key Stat: Kyle Orton 5-1 as starting QB versus division.

You Need To Know: Lovie Smith is 8-1 off a non-division loss versus an opponent off a win.

New Orleans at Carolina

Series History: The visiting team is 13-0 in this series, including 8-1 SU the last nine games.

New Orleans Key Stat: The Saints are 7-1 as a dog versus a .500 or greater opponent under head coach Sean Payton.

Carolina Key Stat: The Panthers are 0-8 as home favorites in October versus .500 or greater opponents.

You Need To Know: New Orleans is the top passing team in the league.  Drew Brees has tossed for 300 or more yards in five of six games this season.

Other Top Trends for this weekend: The dog in the Clemson/Georgia Tech series is 11-1; Wisconsin is 12-1 off BB losses; Alabama is 2-16 in its last 18 games as a conference home favorite; The Chiefs are 10-1 as home dogs versus an opponent off BB SU and ATS wins; The Steelers are 1-7 away off a win under head coach Mike Tomlin; The Bucs are 3-18 ATS in October off a SU and ATS win versus non-division opponents.

This Week's Super System Says: PLAY AGAINST any college football team in Game Seven if they are playing their 5th road game of the season if they allow 21.5 or more PPG and their opponent is off a win.

ATS W-L Record Since 1980: 26-8 (76%)

Play Against: Florida International

> Get Marc's Favorite & Underdog Games of the Week at Pregame Pros!