Negative experiences with both pot (I'm an ex heavy user who was a low energy guy to begin with so, not a good thing for me, for about 15 years but I grew up in the late 60's and had no choice :) ) and alcohol (family alcoholics, functional and non). Your milage can and will vary with both herb and drink but alcohol will do far (far) more damage.
"anyone in this thread actually have thoughts on the Denver/KC game?"
Yes, caught the Under 51 last Sunday and am thinking of adding to that thesis via a teaser. Mediocre K.C. offense that will try and keep the ball away from Manning coupled with a good K.C. defense, divisional rivalry, big game. Manning a little gimpy. The usual over/under wildcards will unfortunately, apply.
The score itself - have to like Denver at home because of K.C.'s average offense but avoiding the call.