The only thing that gives me pause in this one is it's ISU's first road game and a in-state rivalry game. But ISU is 2-1 in neutral site games with the lone loss to a very good Gonzaga team. Meanwhile UI's best win has been against lowly Stetson #286. I don't think it will but it could get tight so I'm buying the off the hook.
2* #519 IOWA ST. -4 -120