Road favorites of -200 or higher are 27-3 (with the 3 losses being by a combined 5 runs) since 2012. The avg. victory is by 3.23 runs per game and these teams yield an ROI of 32%.
These teams on the run line are 21-9 over the same span beating the RL by 1.73 runs per game. This situation yields an ROI of 24.4%.
The A's are a qualifying team for this situation today (unless the line falls to -195 or something). So if you were planning to bet on A's/Astros in some form today, this might be something to consider!